On September 17, 2019 Health Canada released a MedEffect Notice advising of a risk associated with the combination of gabapentin or pregabalin drugs with opioids. The notice links the use of these drugs in combination to opioid overdose and other serious side effects like respiratory depression (slowed breathing), increased sedation (sleepiness), dizziness, fainting, and death.

Gabapentin is commonly known as Neurontin and is prescribed to treat epilepsy, while the related drug pregabalin is commonly known as Lyrica and is prescribed to treat nerve pain.